Tools for in vivo phenotyping of newborn rodents (mice and rats) are pivotal to study animal models of paediatric diseases. To this aim, size and immaturity of newborn animals raise great technical difficulties. We constituted an engineering core (mechanical, electronics, optics, computer science) to develop new methods and devices, and make possible to detect and study early neurodevelopmental disorders in vivo. To date, our phenotyping capability has already no equivalent in the world. Our bio-engineering activity received several awards in the last few years.
Phenopups developed three phenotyping devices to study newborn and juvenile rodents:
- Vital functions testing: PhysioPups device. Measure breathing, ECG, ultrasonic vocalizations, body temperature, movements, metabolism (02 consumption) simultaneously and non-invasively since birth !
- Cognitive testing: Memorypups device. Evaluate learning abilities by classical conditioning tests in newborn mice and rats during the first weeks of life !
- Psychomotor testing: NeoGAIT device. Observe and qualify motor development and gait since birth in rats and mice !